Although luxury and comfort are not the first things that come to mind when you think of the Amazon, you may be surprised by some of the options in this region. There are some nice and comfortable lodges in the Amazon, and when you travel to the city of Leticia, you can also find luxury hotels. Another thing to think about when it comes to luxury, are the private services which can be arranged during the trips into the jungle.
Some of the best options are Calanoa Lodge at the Amazon River, or a private hut at the Palmari Lodge just over the border at the Yavarí River in Brazil. In Leticia a luxury option could be Decalodge Ticuna from Decameron.
When thinking of luxury, you can also think of private services. Hiring a charter plane to get to remote areas, or specialized jungle guides are such services. With a private charter flight, it is also possible to keep travel times short. Trips which normally requires a week, or even longer, can be reduced by using these kinds of transports. Hiring a special jungle expedition guide, or an expert guide for birding, are expensive services, and therefor considered 'luxury' as these kinds of services, will enrich your experience even more.